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CDC guidelines for treatment of antrax
| CDC, USA published the 8 October 2001 Guidelines for treatment of patients infected with antrax or perons who may have been exposed to antrax: |
This is an official CDC Health Update
Distributed via Health Alert Network
Update: Ongoing Investigation of Anthrax in Florida October 8, 2001
Recommendations for Post-Exposure Prophylaxis for Bacillus anthracis in Florida
These recommendations are based on the susceptibility pattern of the B. anthracis isolate from the Florida inhalational anthrax case.
Adult males (ages 18-65 yrs)
Ciprofloxacin 500 mg orally twice a day for 60 days
OR
Doxycycline 100 mg orally twice a day for 60 days
OR
Amoxicillin 500 mg orally three times a day for 60 days
Drug interactions and individual patient allergies should be considered when selecting an antibiotic for prophylaxis.
Non-pregnant adult females (ages 18-65 yrs)
Ciprofloxacin 500 mg orally twice a day for 60 days
OR
Doxycycline 100 mg orally twice a day for 60 days
OR
Amoxicillin 500 mg orally three times a day for 60 days
Drug interactions and individual patient allergies should be considered when selecting an antibiotic prophylaxis.
Pregnant adult females
Amoxicillin 500 mg orally three times a day for 60 days
If allergic to amoxicillin or penicillin, consultation with a physician
is required as ciprofloxacin or doxycycline may be indicated.
Adults age 65 yrs
Doxycycline 100 mg orally twice a day for 60 days
OR
Ciprofloxacin 500 mg orally twice a day for 60 days
OR
Amoxicillin 500 mg orally three times a day for 60 days
Drug-drug interactions and individual patient allergies should be
considered when selecting an antibiotic for prophylaxis.
In older adults, the potential CNS side effects of ciprofloxacin should
also be considered when selecting an antibiotic for prophylaxis.
Antibiotics for children are listed in order of preference:
Children 9 yrs
Amoxicillin 500 mg orally three times a day for 60 days
OR
Ciprofloxacin 500 mg orally twice a day for 60 days
OR
Doxycycline 100 mg orally twice a day for 60 days
Drug-drug interactions and individual patient allergies should beconsidered when selecting an antibiotic for prophylaxis. Amoxicillin is preferred for children. If allergic to amoxicillin or penicillin,consultation with a physician is required as ciprofloxacin or doxycycline may be indicated.
Children < 9 yrs
Amoxicillin 80 mg/kg/day orally, divided into three doses a day for 60 days
OR
Ciprofloxacin 10-15 mg/kg/day orally, divided into two doses a day for 60 days
OR
Doxycycline 5 mg/kg/day orally, divided into two doses a day for 60 days.
Drug-drug interactions and individual patient allergies should be considered when selecting an antibiotic for prophylaxis. Amoxicillin is preferred for children. If allergic to amoxicillin or penicillin, consultation with a physician is required as ciprofloxacin or doxycycline may be indicated.
- Today public health officials in Palm Beach County Health Department began to evaluate and offer prophylactic treatment to persons who mighthave been exposed to Bacillus anthracis (the bacteria that causes anthrax) while working or visiting America Media Inc. (AMI) in Boca Raton, Florida.
- Persons known to have been in the AMI building for at least one hour since August 1, 2001 will be contacted if they have not already been evaluated. Those who are not currently in Florida might seek care in other jurisdictions. Contact your local or State health department if this happens in your jurisdiction, so that the information can be relayed to CDC and the Palm Beach County Health Department. The prophylactic antibiotic treatment regimens recommended for per-sons potentially exposed to B. anthracis at AMI are attached. Additional information aboutprophylactic treatment for anthrax can be found at www.bt.cdc.gov
- Federal agencies and public health officials are continuing to investigate anthrax in Florida.
- No additional cases of anthrax have been identified
- Reminder: symptoms of inhalational anthrax include fever, muscle aches, and fatigue that rapidly progress to severe systemic illness.
- Workers and visitors associate with the AMI worksite in Florida who develop such symptoms should be thoroughly evaluated to exclude anthrax and be reported to the state health department.
FOR ADDITIONAL INFORMATION CALL (404) 639-2807
Edited: 8 October 2002
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