By a journey to Botswana on 1 to 5 months recommend protection against the following infections:

Diphtheria
Diphtheria is a serious throat infection, which infects from person-to-person through the air. The vaccination should be less than 10 years old otherwise a booster is needed.
Read more about diphteria here.

Hepatitis A (infectious hepatitis)
Infectious hepatitis infects through contaminated food and water. Vaccination consists of two injections about 12 months apart, which protects for up to 25 years. The first vaccination protects for 12 months. 
Read more about hepatitis A here.
The hepatitis A vaccine can be combined with the vaccine against hepatitis B

Hepatitis B
Hepatitis B infects through blood, sexual activities and, in small children, through saliva. The vaccination consists of 2 vaccinations about 4 weeks apart and a third 6 months later. The protection is for at least 25 years perhaps life long. 
Read more about hepatitis B here.
The hepatitis B vaccine can be combined with the vaccine against hepatitis A.

HIV in Africa
109 Danes were infected with HIV in Africa between 1991 and 99. Africa is the continent with most HIV infected people. Overall about 8% of the population is infected with infection rates reaching up to 80% in risk groups like prostitutes.
Read more about HIV here.

Tetanus
Tetanus is a complication to wounds contaminated by soil. If there has been a vaccination within the past 10 years it is not necessary to give a booster in case of wounds and accidents. Tetanus vaccinations are usually given in combination with diphtheria vaccine. If you are previously vaccinated, the vaccine can be given right up to departure.

Typhoid
Typhoid is the most serious of the Salmonella infections. There are two types of vaccine: 
1. Vaccine for injection,  one  vaccination protect up to 3 years. 
2. A live vaccine in capsules, which is swallowed. Three capsules are taken 2 days apart and provide protection for a year.
Read more about typhoid here.
Read more about diarrhoea here.

Malaria in Botswana
Malaria risk in Botswana is seen on the map below. The choice is between Malarone, Doxycycline or Lariam. Protection against mosquito bites will reduce the risk further.
The distribution of malaria can be seen at the map below.
Read more about malaria here.

The information on malaria risk in individual countries are based on the sources found here

Recommended vaccinations Starting Diphtheria 1 day Hepatitis A (infectious hepatitis) 1 week Hepatitis B 3 - 4 weeks HIV in Africa Tetanus 1 day Typhoid 1 week Malaria in Botswana 1-7 days 3 - 4 weeks When to start vaccinations before leaving::